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MOTS-c (Mitochondrial ORF of the Twelve S rRNA–C) is a naturally occurring mitochondrial-derived peptide composed of 16 amino acids. It plays a significant role in regulating metabolic homeostasis, cellular energy balance, and stress responses. In preclinical studies, MOTS-c has been shown to enhance glucose metabolism, mitochondrial function, and insulin sensitivity, making it a key focus in research related to longevity, obesity, metabolic disorders, and age-related decline.
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